Научные интересы

Медицинская химия. Поиск и исследование новых потенциальных препаратов для лечения нейродегенеративных заболеваний. Исследование связи структура-биологическая активность соединений. Моделирование нейродегенеративных процессов.

Научные публикации

1. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. S.O. Bachurin, G.F. Makhaeva, E.F. Shevtsova et al., Molecules 2021, 26, 5527. https://doi.org/10.3390/molecules26185527
2. Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease. Shevtsova EF, Maltsev AV, Vinogradova DV, Shevtsov PN, Bachurin SO. Med Res Rev. 2021 Mar;41(2):803-827. doi: 10.1002/med.21715. Epub 2020 Jul 20.
3. Novel Positive Allosteric Modulators of AMPA Receptors Based on 3,7-Diazabicyclo[3.3.1]nonane Scaffold. Lavrov MI, Karlov DS, Voronina TA, Grigoriev VV, Ustyugov AA, Bachurin SO, Palyulin VA. Mol Neurobiol. 2020 Jan;57(1):191-199. doi: 10.1007/s12035-019-01768-6. Epub 2019 Sep 12.Mol Neurobiol. 2020. PMID: 31515692
4. Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases. Bachurin SO, Makhaeva GF, Shevtsova EF, Boltneva NP, Kovaleva NV, Lushchekina SV, Rudakova EV, Dubova LG, Vinogradova DV, Sokolov VB, Aksinenko AY, Fisenko VP, Richardson RJ, Aliev G. Sci Rep. 2019 Mar 19;9(1):4873. doi: 10.1038/s41598-019-41272-4
6. Alzheimer's Disease - Future Therapy Based on Dendrimers. Aliev G, Ashraf GM, Tarasov VV, Chubarev VN, Leszek J, Gasiorowski K, Makhmutovа A, Baeesa SS, Avila-Rodriguez M, Ustyugov AA, Bachurin SO. Curr Neuropharmacol. 2019;17(3):288-294. doi: 10.2174/1570159X16666180918164623
7. Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention. Bachurin SO, Gavrilova SI, Samsonova A, Barreto GE, Aliev G. Pharmacol Res. 2018 Mar;129:216-226. doi: 10.1016/j.phrs.2017.11.021
8. Applications of Multi-Target Computer-Aided Methodologies in Molecular Design of CNS Drugs. Raevsky OA, Mukhametov A, Grigorev VY, Ustyugov A, Tsay SC, Jih-Ru Hwu R, Yarla NS, Tarasov VV, Aliev G, Bachurin SO. Curr Med Chem. 2018;25(39):5293-5314. doi: 10.2174/0929867324666170920154111
9. Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action. Strekalova T, Bahzenova N, Trofimov A, Schmitt-Böhrer AG, Markova N, Grigoriev V, Zamoyski V, Serkova T, Redkozubova O, Vinogradova D, Umriukhin A, Fisenko V, Lillesaar C, Shevtsova E, Sokolov V, Aksinenko A, Lesch KP, Bachurin S. Mol Neurobiol. 2018 Jan;55(1):335-349. doi: 10.1007/s12035-017-0745-6
11. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, Seely L, Hung D; dimebon investigators.Doody RS, et al. Among authors: bachurin so. Lancet. 2008 Jul 19;372(9634):207-15. doi: 10.1016/S0140-6736(08)61074-0.
12. Neuroprotective and cognition-enhancing properties of MK-801 flexible analogs. Structure-activity relationships. Bachurin S, Tkachenko S, Baskin I, Lermontova N, Mukhina T, Petrova L, Ustinov A, Proshin A, Grigoriev V, Lukoyanov N, Palyulin V, Zefirov N.Bachurin S, et al. Ann N Y Acad Sci. 2001 Jun;939:219-36. doi: 10.1111/j.1749-6632.2001.tb03629.x

Премии и награды

Дипломом качества и Золотая медаль Европейской научно-промышленной палаты, 2012

Персональные профили исследователя

Web of Science: I-1708-2018
Scopus: 7007087179
РИНЦ: 51411
ORCID: 0000-0003-3637-818X