Габибов Александр Габибович

Научные интересы

Физико-химическая биология, биохимия, и иммунология, молекулярная биология.

Научные публикации

•‎ DNA hydrolyzing autoantibodies. Shuster AM, Gololobov GV, Kvashuk OA, Bogomolova AE, Smirnov IV, Gabibov AG. Science. 1992 May 1;256(5057):665-7.
•‎ Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: application of the flow linear dichroism technique. Gololobov GV, Chernova EA, Schourov DV, Smirnov IV, Kudelina IA, Gabibov AG. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):254-7.
•‎ Enzyme mimicry by the antiidiotypic antibody approach. Kolesnikov AV, Kozyr AV, Alexandrova ES, Koralewski F, Demin AV, Titov MI, Avalle B, Tramontano A, Paul S, Thomas D, Gabibov AG, Friboulet A. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13526-31.
•‎ Catalytic antibodies in clinical and experimental pathology: human and mouse models. Ponomarenko NA, Durova OM, Vorobiev II, Aleksandrova ES, Telegin GB, Chamborant OG, Sidorik LL, Suchkov SV, Alekberova ZS, Gnuchev NV, Gabibov AG. J Immunol Methods. 2002 Nov 1;269(1-2):197-211.
•‎ Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen. Ponomarenko NA, Durova OM, Vorobiev II, Belogurov AA Jr, Kurkova IN, Petrenko AG, Telegin GB, Suchkov SV, Kiselev SL, Lagarkova MA, Govorun VM, Serebryakova MV, Avalle B, Tornatore P, Karavanov A, Morse HC 3rd, Thomas D, Friboulet A, Gabibov AG. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):281-6.
•‎ Routes to covalent catalysis by reactive selection for nascent protein nucleophiles. Reshetnyak AV, Armentano MF, Ponomarenko NA, Vizzuso D, Durova OM, Ziganshin R, Serebryakova M, Govorun V, Gololobov G, Morse HC 3rd, Friboulet A, Makker SP, Gabibov AG, Tramontano A. J Am Chem Soc. 2007 Dec 26;129(51):16175-82.
•‎ Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics. Smirnov I, Carletti E, Kurkova I, Nachon F, Nicolet Y, Mitkevich VA, Débat H, Avalle B, Belogurov AA Jr, Kuznetsov N, Reshetnyak A, Masson P, Tonevitsky AG, Ponomarenko N, Makarov AA, Friboulet A, Tramontano A, Gabibov A. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15954-9.
•‎ Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody.Ponomarenko N, Chatziefthimiou SD, Kurkova I, Mokrushina Y, Mokrushina Y, Stepanova A, Smirnov I, Avakyan M, Bobik T, Mamedov A, Mitkevich V, Belogurov A Jr, Fedorova OS, Dubina M, Golovin A, Lamzin V, Friboulet A, Makarov AA, Wilmanns M, Gabibov A. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):708-19.
•‎ Robotic QM/MM-driven maturation of antibody combining sites. Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA. Science Adv. 2016 Oct 19;2(10):e1501695.
•‎ Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma. Stepanov AV, Markov OV, Chernikov IV, Gladkikh DV, Zhang H, Jones T, Sen'kova AV, Chernolovskaya EL, Zenkova MA, Kalinin RS, Rubtsova MP, Meleshko AN, Genkin DD, Belogurov AA Jr, Xie J, Gabibov AG, Lerner RA. Sci Adv. 2018 Nov 14;4(11):eaau4580. doi: 10.1126/sciadv.aau4580. eCollection 2018 Nov.

Персональные профили исследователя

•‎ Web of Science: A-8246-2014.
•‎ Scopus: 7006905505.
•‎ РИНЦ: 78605.
•‎ ORCID: 0000-0001-8665-3288.

Место работы и должность

ФГБУН Институт биоорганической химии им. академиков М. М. Шемякина и Ю. А. Овчинникова РАН, директор.