Научные интересы

Структурно-функциональные исследования белковых и пептидных систем. Биотехнологические способы получения противовирусных и противораковых препаратов на основе модифицированных нуклеозидов.

Научные публикации

Fateev, I.V., Antonov, K.V., Konstantinova, I.D., Muravyova, T.I., Seela, F., Esipov, R.S., Miroshnikov, A.I., Mikhailopulo, I.A. The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: The electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases (2014) Beilstein Journal of Organic Chemistry, 10, pp. 1657-1669
Mikhailopulo, I.A., Miroshnikov, A.I. Biologically important nucleosides: Modern trends in biotechnology and application (2011) Mendeleev Communications, 21 (2), pp. 57-68.
Taran, S.A., Verevkina, K.N., Feofanov, S.A., Miroshnikov, A.I. Enzymatic transglycosylation of natural and modified nucleosides by immobilized thermostable nucleoside phosphorylases from Geobacillus stearothermophilus (2009) Russian Journal of Bioorganic Chemistry, 35 (6), pp. 739-745.
Esipov, R.S., Stepanenko, V.N., Chupova, L.A., Boyarskikh, U.A., Filipenko, M.L., Miroshnikov, A.I. Production of recombinant human epidermal growth factor using Ssp dnaB mini-intein system (2008) Protein Expression and Purification, 61 (1), pp. 1-6.
Yagodkin, A., Azhayev, A., Roivainen, J., Antopolsky, M., Kayushin, A., Korosteleva, M., Miroshnikov, A., Randolph, J., Mackie, H. Improved synthesis of trinucleotide phosphoramidites and generation of randomized oligonucleotide libraries (2007) Nucleosides, Nucleotides and Nucleic Acids, 26 (5), pp. 473-497
Chuvikovsky, D.V., Esipov, R.S., Skoblov, Y.S., Chupova, L.A., Muravyova, T.I., Miroshnikov, A.I., Lapinjoki, S., Mikhailopulo, I.A. Ribokinase from E. coli: Expression, purification, and substrate specificity (2006) Bioorganic and Medicinal Chemistry, 14 (18), pp. 6327-6332.
Esipov, R.S., Gurevich, A.I., Chuvikovsky, D.V., Chupova, L.A., Muravyova, T.I., Miroshnikov, A.I. Overexpression of Escherichia coli genes encoding nucleoside phosphorylases in the pET/BI21(DE3) system yields active recombinant enzymes (2002) Protein Expression and Purification, 24 (1), pp. 56-60.
Sergeev, N.V., Gloukhova, N.S., Nazimov, I.V., Gulyaev, V.A., Shvets, S.V., Donetsky, I.A., Miroshnikov, A.I. Monitoring of recombinant human insulin production by narrow-bore reversed-phase high-performance liquid chromatography, high-performance capillary electrophoresis and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (2001) Journal of Chromatography A, 907 (1-2), pp. 131-144
Zavgorodny, S.G., Pechenov, A.E., Shvets, V.I., Miroshnikov, A.I. S, X-acetals in nucleoside chemistry. III1. Synthesis of 2′- and 3′-O-azidomethyl derivatives of ribonucleosides (2000) Nucleosides, Nucleotides and Nucleic Acids, 19 (10-12), pp. 1977-1991
Kayushin, A., Korosteleva, M., Miroshnikov, A. , Large-scale solid-phase preparation of 3′-unprotected trinucleotide phosphotriesters - Precursors for synthesis of trinucleotide phosphoramidites (2000) Nucleosides, Nucleotides and Nucleic Acids, 19 (10-12), pp. 1967-1976

Премии и награды

Медаль «За трудовую доблесть», 1975
Медаль «За трудовую доблесть», 1981
Премия Правительства Российской Федерации в области науки и техники , 1996
Медаль ордена «За заслуги перед Отечеством", 1999
Премия Правительства Российской Федерации в области науки и техники , 1996
Премия Правительства Российской Федерации в области науки и техники , 2005
Орден Дружбы, 2005
Орден Почёта, 2012

Персональные профили исследователя

Web of Science: G-5017-2017
Scopus: 7006592304
РИНЦ: 9613-7847