Власов Валентин Викторович

Научные интересы

Биофармацевтика, терапевтические нуклеиновые кислоты, молекулярная диагностика, бактериофаги.

Научные публикации

• S. A. Kazakov, T. G. Astashkina, S. V. Mamaev, V. V. Vlassov. Site-specific cleavage of single-stranded DNAs at unique sites by a copper dependent redox reaction. Nature, 335, 186-188 (1988).
• L. A. Yakubov, E. A. Deeva, V. F. Zarytova, E. M. Ivanova, A. S. Ryte, L. V. Yurchenko, V. V. Vlassov. Mechanism of oligonucleotides uptake by cells: Involvement of specific receptors? Proc. Natl. Acad. Sci. USA, 86, № 17, 6454-6458 (1989).
• G. Zuber, B. Felden, J. P. Behr, R. Griege, V. V. Vlassov. Cleavage of RNA with imidazole and spermine imidazole constructs: a new approach for probing RNA structure. Nucl. Acids Res., 23, 3161-3168 (1995).
• V. V. Vlassov, R. Giege, J. P. Ebel. Tertiary structure of tRNAs in solution monitored by phosphodiester modification with ethylnitrosourea. Eur. J. Biochem., 119, 51-59 (1981).
• Medvedeva DA, Maslov MA, Serikov RN, Morozova NG, Serebrenikova GA, Sheglov DV, Latyshev AV, Vlassov VV, Zenkova MA. Novel cholesterol-based cationic lipids for gene delivery. J Med Chem. 2009 Nov 12;52(21):6558-68.
• D. G. Knorre, V. V. Vlassov. Affinity modification of biopolymers. CRC Press Inc., Boca Raton, (1989).
• M. A. Podyminogin, V. V. Vlassov, R. Giege. Synthetic RNA-cleaving molecules mimicking ribonuclease A active center. Design and cleavage of tRNA transcripts. Nucleic Acids Res., 21, N 25, 5950-5956 (1993).
• Chernikov I.V., Gladkikh D.V., Meshchaninova M.I., Venyaminova A.G., Zenkova M.A., Vlassov V.V., Chernolovskaya E.L. Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene// Molecular Therapy Nucleic Acids. 2017. V. 6. PP. 209-220. doi:10.1016/j.omtn.2016.12.011.
• Rykova E.Y., Ponomaryova A.A., Zaporozhchenko I.A., Vlassov V.V., Cherdyntseva N.V., Laktionov P.P. Circulating DNA-based lung cancer diagnostics and follow-up: looking for epigenetic markers. Translational cancer research. 2018. V.7 Suppl. 2. P. S153-S170. Doi: 10.21037/tcr.2018.02.08.
• Morozova V.V., Vlassov V.V., Tikunova N.V. Applications of Bacteriophages in the Treatment of Localized Infections in Humans. Frontiers in microbiol. 2018. Aug 2;9:1696. eCollection 2018. doi: 10.3389/fmicb.2018.01696.

Премии и награды

• Государственная премия РФ, 1999 г.
• Орден Дружбы.
• Орден Почёта.

Место работы и должность

Институт химической биологии и фундаментальной медицины СО РАН, научный руководитель.