Член-корреспондент РАН с 02.06.2022. Профессор РАН с 24.04.2018. 

Научные_интересы:
Тонкий органический синтез, гомогенный катализ, синтез природных соединений и их аналогов, природные тетрапирролы и их аналоги, ингибиторы межбелковых взаимодействий, эффект Варбурга, адресная доставки, биосовместимые наночастицы

Web_of_Science_ResearcherID: D-3178-2013
Ссылка_Web_of_Science: https://publons.com/researcher/2658303/alexey-yu-fedorov/
Scopus_Author_ID: 57210239812
Ссылка_Scopus: https://www.scopus.com/authid/detail.uri?authorId=57210239812
РИНЦ_Author_ID: 49219
Ссылка_РИНЦ: https://www.elibrary.ru/author_profile.asp?id=49219
ORCID_ID: 0000-0003-4889-8617
Ссылка_ORCID: https://orcid.org/0000-0003-4889-8617

Научные_публикации:
1: V.F. Otvagin, N.S. Kuzmina, E.S. Kudriashova, A.V. Nyuchev, A.E. Gavryushin, A.Yu. Fedorov. Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy. Journal of Medicinal Chemistry 2022, 65, 3, 1695–1734. https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01953
2: A. Stein, P. Hilken née Thomopoulou, C. Frias, S.M. Hopff, P. Varela, N. Wilke, A. Mariappan, J.-M. Neudörfl, A.Yu. Fedorov, J. Gopalakrishnan, B. Gigant, A. Prokop, H.-G. Schmalz. B-nor-methylene сolchicinoid PT-100 selectively induces apoptosis in multidrug-resistant human cancer cells via an intrinsic pathway in a caspase-independent manner. ACS Omega 2022, 10.1021/acsomega.1c04659. https://pubs.acs.org/doi/abs/10.1021/acsomega.1c04659
3: E.S. Shchegravina, E.V. Svirshchevskaya, S. Combes, D. Allegro, P. Barbier, B. Gigant, P.F. Varela, A.E. Gavryushin, D.A. Kobanova, A.E. Shchekotikhin, A.Yu. Fedorov. Discovery of dihydrofuranoallocolchicinoids - highly potent antimitotic agents with low acute toxicity. Eur. J. Med. Chem., 2020, 207, 112724. https://www.sciencedirect.com/science/article/abs/pii/S0223523420306966?via%3Dihub
4: Iu.A. Gracheva, E.S. Shchegravina, H.-G. Schmalz, I.P. Beletskaya, A.Yu. Fedorov. Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives. J. Med. Chem., 2020, 63, 10618–10651. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00222
5: V.F. Otvagin, N.S. Kuzmina, L.V. Krylova, A.B. Volovetsky, A.V. Nyuchev, A.E. Gavryushin, I.N. Meshkov, Y.G. Gorbunova, Y.V. Romanenko, O.I. Koifman, I.V. Balalaeva, A.Y. Fedorov. Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy. J. Med. Chem., 2019, 62, 24, 11182¬¬–11193. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b01294
6: N.S. Sitnikov, Yu.B. Malysheva, A.Yu. Fedorov, H.-G. Schmalz. Design and Synthesis of New Protease-Triggered CO-Releasing Molecules. Eur. J. Org. Chem., 2019, 40, 6830–6837. https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201901206
7: E.S. Shchegravina, D.S. Tretiakova, A.S. Alekseeva, T.R. Galimzyanov, Y.N. Utkin, Y.A. Ermakov, E.V. Svirshchevskaya, V.V. Negrebetsky, N.Yu. Karpechenko, V.P. Chernikov, N.R. Onishchenko, E.L. Vodovozova, A.Yu. Fedorov, I.A. Boldyrev. Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects. Bioconjugate Chem., 2019, 30 (4), 1098-1113. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00051
8: L. Hoffer, Y.V. Voitovich, B. Raux, K. Carrasco, C. Muller, A.Y. Fedorov, C. Derviaux, A. Amouric, S. Betzi, D. Horvath, A. Varnek , Y. Collette, S. Combes, P. Roche , X. Morelli. Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach. J. Med. Chem., 2018, 61 (13), 5719–5732. https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00653
9: V.F. Otvagin, A.V. Nyuchev, N.S. Kuzmina, I.D. Grishin, A.E. Gavryushin, Yu.V. Romanenko, O.I. Koifman, D.V. Belykh, N.N. Peskova, N.Yu. Shilyagina, I.V. Balalaeva, A.Yu. Fedorov. Synthesis and biological evaluation of new water-soluble photoactive chlorin conjugate for targeted delivery. Eur. J. Med. Chem., 2018, 144, 740–750. http://www.sciencedirect.com/science/article/pii/S0223523417310942
10: E.S. Shchegravina, A.A. Maleev, S.K. Ignatov, Iu.A. Gracheva, A. Stein, H.-G. Schmalz, A.E. Gavryushin, A.A. Zubareva, E.V. Svirshchevskaya, A.Yu. Fedorov. Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids. Eur. J. Med. Chem., 2017, 141, 51–60. https://www.sciencedirect.com/science/article/pii/S0223523417307705?via%3Dihub

Премия_награда_год_присуждения:
1: Thieme Chemistry Journals Award 2008