Научные интересы

Доменная организация эукариотического генома. Роль пространственной организации генома в регуляции транскрипции. Эпигенетические механизмы регуляции транскрипции. Структурно-функциональная организация клеточного ядра. Клеточные ответы на стресс и репарация ДНК.

Научные публикации

• Ulianov SV, Zakharova VV, Galitsyna AA, Kos PI, Polovnikov KE, Flyamer IM, Mikhaleva EA, Khrameeva EE, Germini D, Logacheva MD, Gavrilov AA, Gorsky AS, Nechaev SK, Gelfand MS, Vassetzky YS, Chertovich AV, Shevelyov YY, Razin SV. (2021) Order and stochasticity in the folding of individual Drosophila genomes. Nat Commun 12(1), 41. doi: 10.1038/s41467-020-20292-z.
• Gavrilov AA, Zharikova AA, Galitsyna AA, Luzhin AV, Rubanova NM, Golov AK, Petrova NV, Logacheva MD, Kantidze OL, Ulianov SV, Magnitov MD, Mironov AA, Razin SV. (2020) Studying RNA-DNA interactome by Red-C identifies noncoding RNAs associated with various chromatin types and reveals transcription dynamics. Nucleic Acids Res. 48(12), 6699-6714. doi: 10.1093/nar/gkaa457
• Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, Velichko AK, Lyubitelev AV, Feofanov AV, Gurova KV, Studitsky VM, Razin SV. (2019) The anti-cancer drugs curaxins target spatial genome organization. Nat Commun. 2019 Mar 29;10(1), 1441. doi: 10.1038/s41467-019-09500-7.
• Flyamer IM, Gassler J, Imakaev M, Brandão HB, Ulianov SV, Abdennur N, Razin SV, Mirny LA, Tachibana-Konwalski K. (2017) Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition. Nature 544(7648), 110-114. doi: 10.1038/nature21711. Epub 2017 Mar 29.
• Ulianov SV, Khrameeva EE, Gavrilov AA, Flyamer IM, Kos P, Mikhaleva EA, Penin AA, Logacheva MD, Imakaev MV, Chertovich A, Gelfand MS, Shevelyov YY, Razin SV. (2016) Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains. Genome Res. 26(1), 70-84.
• Gavrilov AA, Gushchanskaya ES, Strelkova O., Zhironkina O., Kireev II, Iarovaia OV, Razin SV. (2013) Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub. Nucleic Acids Res. 41, 3563-3575.
• Iarovaia, O.V., Bystritskiy, A., Ravcheev, D., Hancock, R., Razin, S.V. (2004) Visualization of individual DNA loops and a map of loop domains in the human dystrophin gene. Nucl. Acids Res. 32, 2079-2086.
Lagarkova M.A., Iarovaia O.V. and Razin S.V. 1995. • The large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers. J. Biol. Chem. 270, 20239-20241.
Gromova I.I., Thomsen B., and Razin S.V. 1995. • Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-myc gene locus in living cells and in high-salt extracted nuclei. Proc. Natl. Acad. Sci. USA v. 92, p. 102-106.
• Razin S.V., Petrov P. and Hancock R. 1991. Precise localisation of the a-globin gene claster within one of the 20 to 300 kb DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase II sites in vivo: evidence that the fragments are DNA loops or domains. Proc. Natl. Acad.Sci. USA. v.88 p. 8515-8519.

Премии и награды

• Премия им Н. К. Кольцова, 1997 г.
• Орден академических пальм офицерской степени (Франция), 2016 г.

Персональные профили исследователя

• Web of Science: M-6701-2015.
• Scopus: 24374782900.
• ORCID: 0000-0003-1976-8661.