Научные интересы

молекулярная онкология, онкогены, онкосупрессоры, наномедицина, поиск новых лекарственных препаратов, редактирование генома, молкулярные механизмы сигнальной трансдукции в солидных опухолях

Научные публикации

Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity. Chen Y, Barlev NA, Westergaard O, Jakobsen BK. EMBO J. 1993 Dec 15;12(13):5007-18
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD, Berger SL. Mol Cell. 2001 Dec;8(6):1243-54.
Regulation of p53 activity through lysine methylation. Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D. Nature. 2004 Nov 18;432(7015):353-60.
PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome. Antonov AV, Krestyaninova M, Knight RA, Rodchenkov I, Melino G, Barlev NA. Oncogene. 2014 Mar 27;33(13):1621-8
BTK modulates p53 activity to enhance apoptotic and senescent responses. Althubiti M., Rada M., Samuel J., Escorsa J.M. Najeeb H., Lee K-G., Lam K-P., Jones G.D., Barlev N., Macip S. Cancer Res. 2016 Sep 15;76(18):5405-14.
Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA. Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene. 2017 Feb 16;36(7):922-932
Rossin F, Villella VR, D'Eletto M, Farrace MG, Esposito S, Ferrari E, Monzani R, Occhigrossi L, Pagliarini V, Sette C, Cozza G, Barlev NA, Falasca L, Fimia GM, Kroemer G, Raia V, Maiuri L, Piacentini M. TG2 regulates the heat-shock response by the post-translational modification of HSF1. EMBO Rep 2018 Jul;19(7). pii: e45067
Canfarotta F, Lezina L, Guerreiro A, Czulak J, Petukhov A, Daks A, Smolinska-Kempisty K, Poma A, Piletsky S, Barlev NA. Specific Drug Delivery to Cancer Cells with Double-Imprinted Nanoparticles against Epidermal Growth Factor Receptor. Nano Lett. 2018 Aug 8;18(8):4641-4646.
Fedorova O, Petukhov A, Daks A, Shuvalov O, Leonova T, Vasileva E, Aksenov N, Melino G, Barlev NA. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis. Oncogene. 2019 Mar;38(12):2108-2122. doi: 10.1038/s41388-018-0566-8.
Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. Yan Y, Barlev NA, Haley RH, Berger SL, Marmorstein R. Mol Cell. 2000 Nov;6(5):1195-205.

Премии и награды

Chin Chern Award, 1997 Wistar Institute, Philadelphia, USA

Персональные профили исследователя

Web of Science: K-5268-2017
Scopus:
РИНЦ:
ORCID: 0000–0001-7111–2446
MathSciNet: