Специалист в области биомедицины, биоинженерии и биотехнологии. Область научных интересов: физическая химия белков, белковая инженерия, молекулярные механизмы стабильности белков, передача сигнала в биологических системах в норме и патологии, противоопухолевые/противовирусные белки, нанобиотехнологии, молекулярный механизм болезни Альцгеймера.

Список научных публикаций

•‎ Zakharova N.V., Kononikhin A.S., Indeykina M.I., Bugrova A.E., Strelnikova P., Pekov S., Popov I.A., Kozin S.A., Mitkevich V., Makarov A.A., Nikolaev E.N. Mass spectrometric study of the variety of beta-amyloid proteoforms in Alzheimer's disease. Mass Spec. Rev. (2022) e21775.
•‎ Moskalev A., Guvatova Z., Lopes I.A., Beckett C.W., Kennedy B.K., Magalhaes J.P., Makarov A.A. Targeting aging mechanisms: pharmacological perspectives. Trends in Endocrinology and Metabolism (2022) 33, 266-280.
•‎ Mitkevich V.A., Barykin E.P., Eremina S., Pani B., Katkova-Zhukotskaya O., Polshakov V.I., Adzhubei A.A., Kozin S.A., Mironov A.S., Makarov A.A., Nudler E. Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE. Aging and Disease (2022) 14, DOI:10.14336/AD.2022.0827.
•‎ Gusarov I., Shamovsky I., Pani B., Gautier L., Eremina S., Katkova-Zhukotskaya O., Mironov A., Makarov A.А., Nudler E. Dietary thiols accelerate aging of C. elegans. Nat Commun (2021) 12, 14336, DOI: 10.1038/s41467-021-24634-3.
•‎ Petrushanko I.Y., Mitkevich V.A., Lakunina V.A., Anashkina A.A., Spirin P.V., Rubtsov P.M., Prassolov V.S., Bogdanov N.B., Hänggi P., Fuller W., Makarov A.A., Bogdanova A. Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions. Redox Biol (2017) 13, 310 - 319 DOI: 10.1016/j.redox.2017.05.021.
•‎ Polshakov V.I., Mantsyzov A.B., Kozin S.A., Adzhubei A.A., Zhokhov S.S., van Beek W., Kulikova A.A., Indeykina M.I., Mitkevich V.A., Makarov A.A. A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H. Angew Chem Int Edit (2017) 56, 39, 11734 - 11739 DOI: 10.1002/anie.201704615.
•‎ Adzhubei A.A., Sternberg M.J.E., Makarov A.A. Polyproline-II helix in proteins: structure and function. J. Mol. Biol. (2013) 425, 2100–2132.
•‎ Kononenko A.V., Mitkevich V.A., Atkinson G.C., Tenson T., Dubovaya V.I., Frolova L.Y., Makarov A.A., Hauryliuk V. GTP-dependent structural rearrangement of the eRF1:eRF3 complex and eRF3 sequence motifs essential for PABP binding. Nucleic Acids Res. (2010) 38, 548–558.
•‎ Hauryliuk V., Mitkevich V.A., Eliseeva N.A., Petrushanko I.Yu., Ehrenberg M., Makarov A.A. The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form. Proc. Natl. Acad. Sci. USA (2008) 105, 15678-15683.
•‎ Mitkevich V.A., Kononenko A.V., Petrushanko I.Yu., Yanvarev D.V., Makarov A.A., Kisselev L.L. Termination of translation in eukaryotes is mediated by the quaternary eRF1•eRF3•GTP•Mg2+ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct. Nucleic Acids Res. (2006) 34, 3947-3954.

Член Координационного совета Программы фундаментальных научных исследований в Российской Федерации на долгосрочный период (2021–2030 годы).

Персональные профили исследователя

•‎ Web of Science ResearcherID: P-5279-2016.
•‎ Scopus Author ID: 35494843600.
•‎ РИНЦ Author ID: 173707.
•‎ ORCID ID: 0000-0001-6220-6969.